A metal-based inhibitor of tumor necrosis factor-α.
نویسندگان
چکیده
Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.
منابع مشابه
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 51 36 شماره
صفحات -
تاریخ انتشار 2012